Hexarelin: The Potent GHRP with Cardioprotective Potential
An in-depth research guide to Hexarelin, a hexapeptide GHRP known for producing the strongest GH pulse among GHRPs and unique cardioprotective effects through CD36 receptor binding.
Introduction
Hexarelin is a synthetic hexapeptide (His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) belonging to the growth hormone-releasing peptide (GHRP) family. It is distinguished by producing the most potent GH pulse of any GHRP and by its unique cardioprotective properties.
Chemical Profile
- Sequence: His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
- CAS Number: 140703-51-1
- Molecular Weight: ~887.1 g/mol
What Makes Hexarelin Unique
1. Strongest GH Pulse
Among all GHRPs, Hexarelin produces the highest peak GH levels: | GHRP | Relative GH Pulse | |---|---| | Hexarelin | Strongest | | GHRP-2 | Strong | | GHRP-6 | Strong | | Ipamorelin | Moderate |
2. Cardioprotective Effects
Hexarelin binds to CD36 receptors in cardiac tissue, providing protection against ischemic damage independent of GH release. This effect is unique among GHRPs.
3. 2-Methyl-Trp Modification
The 2-methyl group on tryptophan increases metabolic stability compared to other GHRPs.
Side Effect Profile
| Effect | Hexarelin | Notes |
|---|---|---|
| Cortisol elevation | Moderate | Higher than Ipamorelin |
| Prolactin elevation | Moderate | Dose-dependent |
| Appetite stimulation | Moderate | Less than GHRP-6 |
Specifications
| Parameter | Specification |
|---|---|
| Purity | >= 98% (HPLC) |
| CAS | 140703-51-1 |
Conclusion
Hexarelin is valued for its potency and unique cardioprotective properties. All products for in vitro research use only.