Melanotan II: Melanocortin Receptor Agonist Research Guide
A research overview of Melanotan II (MT2), a cyclic heptapeptide analogue of alpha-MSH studied for its potent melanocortin receptor agonism, skin pigmentation effects, and metabolic implications.
Introduction
Melanotan II (MT2) is a synthetic cyclic lactam analogue of alpha-melanocyte-stimulating hormone (alpha-MSH). It acts as a non-selective agonist at melanocortin receptors (MC1R, MC3R, MC4R, MC5R), producing effects on skin pigmentation, appetite, and libido.
Chemical Profile
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- CAS Number: 121062-08-6
- Molecular Weight: ~1,013.2 g/mol
- Appearance: White to off-white lyophilized powder
Mechanism of Action
MT2 activates melanocortin receptors with varying affinity: | Receptor | Primary Effect | |---|---| | MC1R | Skin pigmentation (melanogenesis) | | MC3R | Energy homeostasis, metabolism | | MC4R | Appetite suppression, sexual function | | MC5R | Sebum production |
Preclinical Research
Melanogenesis
- Stimulates melanin production in melanocytes
- Provides UV-independent tanning
- 1,000x more potent than natural alpha-MSH at MC1R
Metabolic Effects
- Appetite suppression via MC4R activation
- Increased lipolysis in adipose tissue
- Weight reduction in animal models
Sexual Function
- MC4R activation influences erectile function
- Studies in preclinical models show enhanced sexual response
Dosing Considerations in Research
| Parameter | Typical Research Range |
|---|---|
| Reconstitution | 2mL BAC water per 10mg vial |
| Concentration | 5mg/mL |
| Starting dose | Low, gradually titrated |
Side Effect Profile
| Effect | Frequency | Notes |
|---|---|---|
| Flushing | Common | MC1R mediated |
| Nausea | Common | Central MC receptor |
| Hyperpigmentation | Expected | Primary effect |
| Spontaneous erections | Common (male) | MC4R mediated |
| Mole darkening | Variable | Pre-existing moles darken |
Specifications
| Parameter | Specification |
|---|---|
| Purity | >= 98% (HPLC) |
| CAS | 121062-08-6 |
Storage
- Lyophilized: -20C (dark, desiccated)
- Reconstituted: 4C, 30 days (light-sensitive)
Conclusion
MT2 is a potent melanocortin agonist with applications in pigmentation and metabolism research. All products for in vitro research use only.