Melanotan II
Synthetic cyclic α-MSH analogue studied for MC3-R and MC4-R receptor agonism and melanocortin pathway modulation.
Also known as: MT-II, α-MSH Analogue
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A synthetic cyclic lactam heptapeptide analogue of the endogenous hormone alpha-melanocyte-stimulating hormone (α-MSH), investigated for potent and selective agonism at melanocortin-3 and melanocortin-4 receptors. Studied in preclinical neuroendocrine research for MC3-R/MC4-R receptor binding kinetics, downstream cAMP and IP3 signalling cascade activation, melanocyte pigment production pathway modulation, and appetite regulation mechanisms. Used as a research tool in melanocortin receptor selectivity profiling, appetite suppression pathway mechanistic studies, and comparative α-MSH analogue receptor interaction studies.
Properties
| Amino Acid Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
|---|---|
| Appearance | White lyophilised powder |
| Cas Number | 121062-08-6 |
| Form | Lyophilized powder |
| Heavy Metals | None Detected |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ |
| Molecular Weight | ~1024.18 g/mol |
| Pubchem Cid | PubChem CID: 91932 ↗ |
| Purity | ≥95% (HPLC) |
| Solubility | Soluble in water (≥5 mg/mL) and bacteriostatic water. Store reconstituted solution in dark. |
| Storage | Store at -20°C in a dry environment. Reconstitute with bacteriostatic water. |
| Structure | Cyclic heptapeptide via lactam bridge |
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