GHRP-2: Growth Hormone Releasing Peptide-2 Research Guide
An evidence-based overview of GHRP-2 (D-Ala-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide GHS-R1a agonist studied for its potent GH-releasing effects and synergistic action with GHRH analogues.
Introduction
GHRP-2 is a synthetic hexapeptide growth hormone secretagogue that acts as a potent agonist of the ghrelin receptor (GHS-R1a). It is one of the most studied compounds in the GHRP family.
Chemical Profile
- Sequence: D-Ala-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2
- Molecular Formula: C45H55N9O6
- CAS Number: 158861-67-7
- Molecular Weight: ~818.0 g/mol
Mechanism of Action
GHRP-2 binds to GHS-R1a receptors in the pituitary and hypothalamus, mimicking ghrelin to stimulate GH release. Unlike GHRH, which acts through a separate receptor, GHRP-2 uses an entirely different pathway, making it synergistic with GHRH analogues like CJC-1295.
Comparison with Other GHRPs
| Parameter | GHRP-2 | GHRP-6 | Ipamorelin |
|---|---|---|---|
| GH pulse intensity | Strong | Strong | Moderate |
| Cortisol elevation | Mild | Moderate | None |
| Prolactin elevation | Mild | Mild | None |
| Appetite stimulation | Moderate | Strong | Minimal |
| CAS | 158861-67-7 | 87616-84-0 | 170851-70-4 |
Preclinical Research
GH Release
- Rapid onset (15-30 min peak)
- Pulsatile release pattern maintained
- Synergistic with GHRH analogues (2-5x amplification)
Metabolic Effects
- Enhanced lipolysis
- Improved nitrogen retention
- Increased IGF-1 production
Analytical Specifications
| Parameter | Specification |
|---|---|
| Purity | >= 98% (HPLC) |
| Identity | MS confirmed |
| Peptide content | >= 85% |
Storage
- Lyophilized: -20C, 2-5 years
- Reconstituted: 4C, 30 days (bacteriostatic water)
Conclusion
GHRP-2 is a well-characterised research tool for growth hormone studies. All products are for in vitro research use only.