Selank
Synthetic tuftsin analogue studied for GABAergic modulation
Also known as: Thr-Lys-Pro-Arg-Pro-Gly-Pro
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A synthetic heptapeptide analogue of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended with a Gly-Glu-Pro-Arg sequence to confer proteolytic stability. Investigated in preclinical models for interactions with the GABAergic system, modulation of IL-6, IL-1β, and TNF-α expression, and enkephalin degradation inhibition.
Properties
| Appearance | White to off-white lyophilized powder |
|---|---|
| Cas Number | 129954-34-3 |
| Form | Lyophilized powder |
| Heavy Metals | None Detected |
| Molecular Formula | C33H55N11O8 |
| Molecular Weight | ~751.9 g/mol |
| Pubchem Cid | PubChem CID: 129954-34-3 ↗ |
| Purity | ≥98% (HPLC) |
| Solubility | Soluble in water (≥10 mg/mL). |
| Storage | Store at -20°C. |
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Frequently Asked Questions
Selank is a synthetic analogue of the immunomodulatory peptide Tuftsin. It is a neuropeptide studied for its anxiolytic, nootropic, and immunomodulatory properties in preclinical research models. It acts on the GABAergic system and modulates interleukin expression.