TB-500 Dosage Guide: Research Protocols and Preparation
Detailed dosage protocols for TB-500 (Thymosin Beta-4 fragment) research, including reconstitution concentrations, administration routes, and cycling schedules used in preclinical studies.
Introduction
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tb4), a 43-amino-acid peptide with demonstrated wound-healing and tissue-repair properties. This guide covers research-appropriate dosage protocols.
Chemical Profile
- Sequence: Ac-LKKTETQ (N-terminal fragment of Tb4)
- CAS Number: 77591-33-4
- Molecular Weight: ~4,963 Da (full Tb4)
- Appearance: White lyophilized powder
Reconstitution
| Vial Size | BAC Water | Concentration |
|---|---|---|
| 2mg | 1mL | 2mg/mL |
| 5mg | 2.5mL | 2mg/mL |
| 10mg | 5mL | 2mg/mL |
Research Dosage Protocols
Phase 1: Loading (4-6 weeks)
- 2-2.5mg subcutaneous, twice weekly
- Total weekly: 4-5mg
Phase 2: Maintenance (4-6 weeks)
- 1-1.5mg once weekly
- Total weekly: 1-1.5mg
Phase 3: Off Cycle
- 4-8 weeks off before another cycle
Mechanism of Action
TB-500 upregulates actin sequestration, promoting cell migration and angiogenesis. It also modulates inflammatory cytokines and promotes collagen deposition at injury sites.
Frequently Asked Questions
What is the CAS number for TB-500?
77591-33-4 (full Thymosin Beta-4)
How should TB-500 be stored?
Lyophilized: -20C. Reconstituted: 2-8C for up to 30 days.
Conclusion
TB-500 represents a promising tool for tissue repair research. All products are for in vitro research use only.