AOD-9604: The Lipolytic Fragment of Human Growth Hormone
A research guide to AOD-9604, a modified C-terminal fragment of hGH (aa 177-191) studied for its lipolytic effects without the diabetogenic or growth-promoting activity of full-length growth hormone.
Introduction
AOD-9604 is a synthetic peptide corresponding to amino acids 177-191 of human growth hormone (hGH), modified with a tyrosine at the N-terminus. It was developed by Metabolic Pharmaceuticals specifically for its fat-reducing properties.
Chemical Profile
- Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
- CAS Number: 221231-10-3
- Molecular Weight: ~1817.1 g/mol
- Appearance: White lyophilized powder
Mechanism of Action
AOD-9604 mimics the lipolytic (fat-burning) domain of hGH without triggering:
- Insulin-like growth factor 1 (IGF-1) production
- Cell proliferation (no tissue growth effects)
- Diabetogenic activity (no insulin resistance)
The peptide activates beta-3 adrenergic receptors in adipose tissue, stimulating lipolysis and inhibiting lipogenesis simultaneously.
Preclinical Research
Lipolysis Studies
- Stimulates triglyceride breakdown in isolated adipocytes
- 10x more potent than the native hGH fragment at equivalent concentrations
- Does not affect blood glucose levels
Obesity Research
- In animal models of diet-induced obesity, reduced body weight by 8-15%
- Effects were specific to adipose tissue (no muscle loss)
- No rebound weight gain observed after discontinuation
Cartilage Repair
Recent studies suggest AOD-9604 may promote cartilage repair in osteoarthritis models.
Specifications
| Parameter | Specification |
|---|---|
| Purity | >= 98% (HPLC) |
| Identity | MS confirmed |
| CAS | 221231-10-3 |
Storage
- Lyophilized: -20C
- Reconstituted: 4C, 30 days
Conclusion
AOD-9604 represents a targeted approach to fat metabolism research. All products for in vitro research use only.